abstract：:Proper control of hepatic glucose production is central to whole-body glucose homeostasis, and its disruption plays a major role in diabetes. Here, we demonstrate that although established as an intracellular lipid chaperone, aP2 is in fact actively secreted from adipocytes to control liver glucose metabolism. Secreti...

journal_title：Cell metabolism

authors： Cao H,Sekiya M,Ertunc ME,Burak MF,Mayers JR,White A,Inouye K,Rickey LM,Ercal BC,Furuhashi M,Tuncman G,Hotamisligil GS

更新日期：2013-05-07 00:00:00

abstract：:Autophagy is a catabolic process that ensures homeostatic cell clearance and is deregulated in a growing number of myopathological conditions. Although FoxO3 was shown to promote the expression of autophagy-related genes in skeletal muscle, the mechanisms triggering autophagy are unclear. We show that TSC1-deficient m...

journal_title：Cell metabolism

authors： Castets P,Lin S,Rion N,Di Fulvio S,Romanino K,Guridi M,Frank S,Tintignac LA,Sinnreich M,Rüegg MA

更新日期：2013-05-07 00:00:00

abstract：:Whether some hypothalamic neurons have direct access to circulating metabolic cues represents a crucial question that has been intensely debated. New findings reveal that fasting promotes "leakiness" of some hypothalamic blood vessels, increasing the access of circulating factors to certain hypothalamic neurons that c...

journal_title：Cell metabolism

authors： Myers MG Jr

更新日期：2013-04-02 00:00:00

abstract：:The delivery of blood-borne molecules conveying metabolic information to neural networks that regulate energy homeostasis is restricted by brain barriers. The fenestrated endothelium of median eminence microvessels and tight junctions between tanycytes together compose one of these. Here, we show that the decrease in ...

journal_title：Cell metabolism

authors： Langlet F,Levin BE,Luquet S,Mazzone M,Messina A,Dunn-Meynell AA,Balland E,Lacombe A,Mazur D,Carmeliet P,Bouret SG,Prevot V,Dehouck B

更新日期：2013-04-02 00:00:00

abstract：:Circulating levels of insulin and glucagon reflect the nutritional state of animals and elicit regulatory responses in the liver that maintain glucose and lipid homeostasis. The transcription factor Foxa2 activates lipid metabolism and ketogenesis during fasting and is inhibited via insulin-PI3K-Akt signaling-mediated...

journal_title：Cell metabolism

authors： von Meyenn F,Porstmann T,Gasser E,Selevsek N,Schmidt A,Aebersold R,Stoffel M

更新日期：2013-03-05 00:00:00

abstract：:Iron overload is a risk factor for diabetes. The link between iron and diabetes was first recognized in pathologic conditions-hereditary hemochromatosis and thalassemia-but high levels of dietary iron also impart diabetes risk. Iron plays a direct and causal role in diabetes pathogenesis mediated both by β cell failur...

journal_title：Cell metabolism

authors： Simcox JA,McClain DA

更新日期：2013-03-05 00:00:00

abstract：:Neuropepetide Y (NPY) is best known for its powerful stimulation of food intake and its effects on reducing energy expenditure. However, the pathways involved and the regulatory mechanisms behind this are not well understood. Here we demonstrate that NPY derived from the arcuate nucleus (Arc) is critical for the contr...

journal_title：Cell metabolism

authors： Shi YC,Lau J,Lin Z,Zhang H,Zhai L,Sperk G,Heilbronn R,Mietzsch M,Weger S,Huang XF,Enriquez RF,Baldock PA,Zhang L,Sainsbury A,Herzog H,Lin S

更新日期：2013-02-05 00:00:00

abstract：:Reduced reproduction is associated with increased fat storage and prolonged life span in multiple organisms, but the underlying regulatory mechanisms remain poorly understood. Recent studies in several species provide evidence that reproduction, fat metabolism, and longevity are directly coupled. For instance, germlin...

journal_title：Cell metabolism

authors： Hansen M,Flatt T,Aguilaniu H

更新日期：2013-01-08 00:00:00

abstract：:Mice lacking the Jak tyrosine kinase member Tyk2 become progressively obese due to aberrant development of Myf5+ brown adipose tissue (BAT). Tyk2 RNA levels in BAT and skeletal muscle, which shares a common progenitor with BAT, are dramatically decreased in mice placed on a high-fat diet and in obese humans. Expressio...

journal_title：Cell metabolism

authors： Derecka M,Gornicka A,Koralov SB,Szczepanek K,Morgan M,Raje V,Sisler J,Zhang Q,Otero D,Cichy J,Rajewsky K,Shimoda K,Poli V,Strobl B,Pellegrini S,Harris TE,Seale P,Russell AP,McAinch AJ,O'Brien PE,Keller SR,Cronig

更新日期：2012-12-05 00:00:00

abstract：:Evolution favored individuals with superior cognitive and physical abilities under conditions of limited food sources, and brain function can therefore be optimized by intermittent dietary energy restriction (ER) and exercise. Such energetic challenges engage adaptive cellular stress-response signaling pathways in neu...

journal_title：Cell metabolism

authors： Mattson MP

更新日期：2012-12-05 00:00:00

abstract：:We sequenced Drosophila head RNA to identify a small set of miRNAs that undergo robust circadian cycling. We concentrated on a cluster of six miRNAs, mir-959-964, all of which peak at about ZT12 or lights off. The cluster pri-miRNA is transcribed under bona fide circadian transcriptional control, and all six mature mi...

journal_title：Cell metabolism

authors： Vodala S,Pescatore S,Rodriguez J,Buescher M,Chen YW,Weng R,Cohen SM,Rosbash M

更新日期：2012-11-07 00:00:00

abstract：:The symbiotic gut microbiota modulate health and disease of the host through a series of transgenomic metabolic and immune regulatory axes. We explore connections between microbiome composition and function related to individual metabolic phenotypes and consider these interactions as possible targets for developing ne...

journal_title：Cell metabolism

authors： Holmes E,Li JV,Marchesi JR,Nicholson JK

更新日期：2012-11-07 00:00:00

abstract：:XBP1 is a key regulator of the unfolded protein response (UPR), which is involved in a wide range of physiological and pathological processes. XBP1 ablation in liver causes profound hypolipidemia in mice, highlighting its critical role in lipid metabolism. XBP1 deficiency triggers feedback activation of its upstream e...

journal_title：Cell metabolism

authors： So JS,Hur KY,Tarrio M,Ruda V,Frank-Kamenetsky M,Fitzgerald K,Koteliansky V,Lichtman AH,Iwawaki T,Glimcher LH,Lee AH

更新日期：2012-10-03 00:00:00

abstract：:Studying ciliopathies, like the Bardet-Biedl syndrome (BBS), allow the identification of signaling pathways potentially involved in common diseases, sharing phenotypic features like obesity or type 2 diabetes. Given the close association between obesity and insulin resistance, obese BBS patients would be expected to b...

journal_title：Cell metabolism

authors： Marion V,Mockel A,De Melo C,Obringer C,Claussmann A,Simon A,Messaddeq N,Durand M,Dupuis L,Loeffler JP,King P,Mutter-Schmidt C,Petrovsky N,Stoetzel C,Dollfus H

更新日期：2012-09-05 00:00:00

abstract：:Adipose tissue plays an important role in storing excess nutrients and preventing ectopic lipid accumulation in other organs. Obesity leads to excess lipid storage in adipocytes, resulting in the generation of stress signals and the derangement of metabolic functions. SIRT1 is an important regulatory sensor of nutrien...

journal_title：Cell metabolism

authors： Chalkiadaki A,Guarente L

更新日期：2012-08-08 00:00:00

abstract：:Obesity and atherosclerosis-related diseases account for over one-third of deaths in the western world. Controlling these conditions remains a major challenge due to an incomplete understanding of the molecular pathways involved. Here, we show that Wip1 phosphatase, a known negative regulator of Atm-dependent signalin...

journal_title：Cell metabolism

authors： Le Guezennec X,Brichkina A,Huang YF,Kostromina E,Han W,Bulavin DV

更新日期：2012-07-03 00:00:00

abstract：:In the face of the current obesity epidemic, the nature of the relationship between overnutrition and type 2 diabetes is of great importance. Obesity can be considered a state of excessive insulin action that elicits a series of cellular homeostatic responses, producing systemic insulin resistance. These responses occ...

journal_title：Cell metabolism

authors： Saltiel AR

更新日期：2012-06-06 00:00:00

abstract：:Nonalcoholic fatty liver disease (NAFLD) is now the most frequent chronic liver disease in Western societies, affecting one in four adults in the USA, and is strongly associated with hepatic insulin resistance, a major risk factor in the pathogenesis of type 2 diabetes. Although the cellular mechanisms underlying this...

journal_title：Cell metabolism

authors： Jornayvaz FR,Shulman GI

更新日期：2012-05-02 00:00:00

abstract：:Resveratrol induces mitochondrial biogenesis and protects against metabolic decline, but whether SIRT1 mediates these benefits is the subject of debate. To circumvent the developmental defects of germline SIRT1 knockouts, we have developed an inducible system that permits whole-body deletion of SIRT1 in adult mice. Mi...

journal_title：Cell metabolism

authors： Price NL,Gomes AP,Ling AJ,Duarte FV,Martin-Montalvo A,North BJ,Agarwal B,Ye L,Ramadori G,Teodoro JS,Hubbard BP,Varela AT,Davis JG,Varamini B,Hafner A,Moaddel R,Rolo AP,Coppari R,Palmeira CM,de Cabo R,Baur JA,Sin

更新日期：2012-05-02 00:00:00

abstract：:Nutritional and pharmacological stimuli can dramatically alter the cellular phenotypes in white adipose tissue (WAT). Utilizing genetic lineage tracing techniques, we demonstrate that brown adipocytes (BA) that are induced by β3-adrenergic receptor activation in abdominal WAT arise from the proliferation and different...

journal_title：Cell metabolism

authors： Lee YH,Petkova AP,Mottillo EP,Granneman JG

更新日期：2012-04-04 00:00:00

abstract：:In advanced atherosclerosis, macrophage apoptosis coupled with defective phagocytic clearance of the apoptotic cells (efferocytosis) promotes plaque necrosis, which precipitates acute atherothrombotic cardiovascular events. Oxidative and endoplasmic reticulum (ER) stress in macrophages are important causes of advanced...

journal_title：Cell metabolism

authors： Liao X,Sluimer JC,Wang Y,Subramanian M,Brown K,Pattison JS,Robbins J,Martinez J,Tabas I

更新日期：2012-04-04 00:00:00

abstract：:The biogenesis and function of the mitochondrial respiratory chain (RC) involve the organization of RC enzyme complexes in supercomplexes or respirasomes through an unknown biosynthetic process. This leads to structural interdependences between RC complexes, which are highly relevant from biological and biomedical per...

journal_title：Cell metabolism

authors： Moreno-Lastres D,Fontanesi F,García-Consuegra I,Martín MA,Arenas J,Barrientos A,Ugalde C

更新日期：2012-03-07 00:00:00

abstract：:The complexes of the electron transport chain associate into large macromolecular assemblies, which are believed to facilitate efficient electron flow. We have identified a conserved mitochondrial protein, named respiratory supercomplex factor 1 (Rcf1-Yml030w), that is required for the normal assembly of respiratory s...

journal_title：Cell metabolism

authors： Chen YC,Taylor EB,Dephoure N,Heo JM,Tonhato A,Papandreou I,Nath N,Denko NC,Gygi SP,Rutter J

更新日期：2012-03-07 00:00:00

abstract：:Plasticity in growth and reproductive behavior is found in many vertebrate species, but is common in male teleost fish. Typically, "bourgeois" males are considerably larger and defend breeding territories while "parasitic" variants are small and use opportunistic breeding strategies. The P locus mediates this phenotyp...

journal_title：Cell metabolism

authors： Zhang C,Forlano PM,Cone RD

更新日期：2012-02-08 00:00:00

abstract：:Several lines of evidence suggest that mitochondrial dysfunction plays a critical role in the pathogenesis of microvascular complications of diabetes, including diabetic nephropathy. However, the signaling pathways by which hyperglycemia leads to mitochondrial dysfunction are not fully understood. Here we examined the...

journal_title：Cell metabolism

authors： Wang W,Wang Y,Long J,Wang J,Haudek SB,Overbeek P,Chang BH,Schumacker PT,Danesh FR

更新日期：2012-02-08 00:00:00

abstract：:Transgenerational inheritance of epigenetic characteristics in plants has been reported, whereas nongenetic persistence of complex phenotypes in animals is controversial. A recent report by Anne Brunet and colleagues describes a fascinating example of persistence across generations of extended life span in worm and ex...

journal_title：Cell metabolism

authors： Berger SL

更新日期：2012-01-04 00:00:00

abstract：:Because MYC plays a causal role in many human cancers, including those with hypoxic and nutrient-poor tumor microenvironments, we have determined the metabolic responses of a MYC-inducible human Burkitt lymphoma model P493 cell line to aerobic and hypoxic conditions, and to glucose deprivation, using stable isotope-re...

journal_title：Cell metabolism

authors： Le A,Lane AN,Hamaker M,Bose S,Gouw A,Barbi J,Tsukamoto T,Rojas CJ,Slusher BS,Zhang H,Zimmerman LJ,Liebler DC,Slebos RJ,Lorkiewicz PK,Higashi RM,Fan TW,Dang CV

更新日期：2012-01-04 00:00:00

abstract：:The serine-threonine protein kinase Akt2, also known as PKBβ, has been shown to regulate glucose and lipid metabolism in animal models. In a recent study published in Science, Hussain et al. (2011) report that in human subjects an activating mutation of Akt2 leads to hypoglycemia and, unexpectedly, asymmetric overgrow...

journal_title：Cell metabolism

authors： Wan M,Birnbaum MJ

更新日期：2011-12-07 00:00:00

abstract：:The brain melanocortin system is a primary gateway through which energy balance is controlled. Diano and colleagues report a novel cellular mechanism mediated via reactive oxygen species (ROS) that regulates the activity of these melanocortin neurons in response to energy status, thereby modulating appetitive behavior...

journal_title：Cell metabolism

authors： Rochford JJ,Myers MG Jr,Heisler LK

更新日期：2011-11-02 00:00:00

abstract：:Lipid droplets (LDs) are cellular storage organelles for neutral lipids that vary in size and abundance according to cellular needs. Physiological conditions that promote lipid storage rapidly and markedly increase LD volume and surface. How the need for surface phospholipids is sensed and balanced during this process...

journal_title：Cell metabolism

authors： Krahmer N,Guo Y,Wilfling F,Hilger M,Lingrell S,Heger K,Newman HW,Schmidt-Supprian M,Vance DE,Mann M,Farese RV Jr,Walther TC

更新日期：2011-10-05 00:00:00

abstract：:Iron-dependent degradation of iron-regulatory protein 2 (IRP2) is a key event for maintenance of an appropriate intracellular concentration of iron. Although FBXL5 (F box and leucine-rich repeat protein 5) is thought to mediate this degradation, the role of FBXL5 in the control of iron homeostasis in vivo has been poo...

journal_title：Cell metabolism

authors： Moroishi T,Nishiyama M,Takeda Y,Iwai K,Nakayama KI

更新日期：2011-09-07 00:00:00

abstract：:Age-related loss of muscle mass and force (sarcopenia) contributes to disability and increased mortality. Ryanodine receptor 1 (RyR1) is the skeletal muscle sarcoplasmic reticulum calcium release channel required for muscle contraction. RyR1 from aged (24 months) rodents was oxidized, cysteine-nitrosylated, and deplet...

journal_title：Cell metabolism

authors： Andersson DC,Betzenhauser MJ,Reiken S,Meli AC,Umanskaya A,Xie W,Shiomi T,Zalk R,Lacampagne A,Marks AR

更新日期：2011-08-03 00:00:00

abstract：:We review mechanisms that regulate production of glucose by the liver, focusing on areas of budding consensus, and endeavoring to provide a candid assessment of lingering controversies. We also attempt to reconcile data from tracer studies in humans and large animals with the growing compilation of mouse knockouts tha...

journal_title：Cell metabolism

authors： Lin HV,Accili D

更新日期：2011-07-06 00:00:00

abstract：:Systemic bile acid (BA) homeostasis is a critical determinant of dietary fat digestion, enterohepatic function, and postprandial thermogenesis. However, major checkpoints for the dynamics and the molecular regulation of BA homeostasis remain unknown. Here we show that hypothalamic-pituitary-adrenal (HPA) axis impairme...

journal_title：Cell metabolism

authors： Rose AJ,Berriel Díaz M,Reimann A,Klement J,Walcher T,Krones-Herzig A,Strobel O,Werner J,Peters A,Kleyman A,Tuckermann JP,Vegiopoulos A,Herzig S

更新日期：2011-07-06 00:00:00

abstract：:The diurnally active fruit flies prefer a major meal in the morning. Feeding the flies in the evening uncouples their metabolic cycle from circadian activity rhythms. A paper by Xu et al. in this issue of Cell Metabolism found that such uncoupled rhythms reduce egg laying. ...

journal_title：Cell metabolism

authors： Gill S,Panda S

更新日期：2011-06-08 00:00:00

abstract：:PTPMT1 was the first protein tyrosine phosphatase found localized to the mitochondria, but its biological function was unknown. Herein, we demonstrate that whole body deletion of Ptpmt1 in mice leads to embryonic lethality, suggesting an indispensable role for PTPMT1 during development. Ptpmt1 deficiency in mouse embr...

journal_title：Cell metabolism

authors： Zhang J,Guan Z,Murphy AN,Wiley SE,Perkins GA,Worby CA,Engel JL,Heacock P,Nguyen OK,Wang JH,Raetz CR,Dowhan W,Dixon JE

更新日期：2011-06-08 00:00:00

abstract：:Type 2 diabetes is an epidemic disease worldwide, but it is difficult to predict its appearance in the general population. A recent study demonstrates that circulating concentrations of a small group of essential amino acids predict risk for diabetes, contributing to a recent resurgence of interest in these common ana...

journal_title：Cell metabolism

authors： Shah SH,Svetkey LP,Newgard CB

更新日期：2011-05-04 00:00:00

abstract：:Serotonin (5-HT) and leptin play important roles in the modulation of energy balance. Here we investigated mechanisms by which leptin might interact with CNS 5-HT pathways to influence appetite. Although some leptin receptor (LepRb) neurons lie close to 5-HT neurons in the dorsal raphe (DR), 5-HT neurons do not expres...

journal_title：Cell metabolism

authors： Lam DD,Leinninger GM,Louis GW,Garfield AS,Marston OJ,Leshan RL,Scheller EL,Christensen L,Donato J Jr,Xia J,Evans ML,Elias C,Dalley JW,Burdakov DI,Myers MG Jr,Heisler LK

更新日期：2011-05-04 00:00:00

abstract：:Cutting down calories prolongs life, but how this works remains largely unknown. A recent study in Nature (Mair et al., 2011) shows that life span extension triggered by the energy-sensing protein kinase AMPK is mediated by an evolutionarily conserved transcriptional circuit involving CRTC-1 and CREB. ...

journal_title：Cell metabolism

authors： Brunet A

更新日期：2011-04-06 00:00:00

abstract：:SIRT1 regulates energy homeostasis by controlling the acetylation status and activity of a number of enzymes and transcriptional regulators. The fact that NAD(+) levels control SIRT1 activity confers a hypothetical basis for the design of new strategies to activate SIRT1 by increasing NAD(+) availability. Here we show...

journal_title：Cell metabolism

authors： Bai P,Cantó C,Oudart H,Brunyánszki A,Cen Y,Thomas C,Yamamoto H,Huber A,Kiss B,Houtkooper RH,Schoonjans K,Schreiber V,Sauve AA,Menissier-de Murcia J,Auwerx J

更新日期：2011-04-06 00:00:00